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Related Experiment Video

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Author Spotlight: Exploring the Potential of Massage Therapy in Cerebral Palsy Using Animal Models

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Emerging drugs for progressive supranuclear palsy.

Nikolaos Giagkou¹, Maria Stamelou^1,2

¹a Parkinson's disease and Movement Disorders Department , Hygeia Hospital , Athens , Greece.

Expert Opinion on Emerging Drugs

|April 23, 2019

Summary

New drugs targeting disease mechanisms show promise for progressive supranuclear palsy (PSP) and other tauopathies. Clinical trials are underway, offering hope for effective treatments and improved patient care.

Keywords:

Clinical trials Progressive supranuclear palsy Tau immunotherapy parkinsonism tau targeted therapeutics tauopathies treatment

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Area of Science:

Neuroscience
Pharmacology
Neurology

Background:

Progressive supranuclear palsy (PSP) is a severe neurodegenerative disease causing atypical parkinsonism.
It significantly impacts patients and caregivers due to its rapid progression.
Current research focuses on disease-modifying therapies targeting PSP pathogenesis.

Purpose of the Study:

To review drugs in Phase 1 and 2 trials for PSP.
To examine Phase 2 trials of these drugs in other tauopathies, such as Alzheimer's disease.
To discuss the therapeutic potential and challenges in PSP drug development.

Main Methods:

Literature review of ongoing clinical trials.
Analysis of drug candidates targeting PSP and tauopathy mechanisms.
Evaluation of tools for assessing treatment efficacy.

Main Results:

Several disease-modifying drugs are in early-phase clinical trials for PSP.
These compounds target key pathological pathways in tauopathies.
Promising therapeutic strategies are emerging for PSP and related disorders.

Conclusions:

Current drug development efforts offer hope for a therapeutic breakthrough in PSP.
Validated biomarkers are crucial for advancing clinical trials and personalized treatment.
Successful therapies could benefit patients with PSP and other tauopathies.