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Related Concept Videos

Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
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Pharmaceutical Equivalents01:26

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As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
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Equivalent Capacitance01:19

Equivalent Capacitance

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Multiple capacitors can be connected in a circuit in series or parallel configuration. When the capacitor combination is connected to a battery, the potential drop across each capacitor and the magnitude of charge stored in the individual capacitor depends on the type of the connection. The capacitor combination is replaced by a single equivalent capacitor that stores the same amount of charge as the combination for a given potential difference.
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Equivalent Capacitance01:19

Equivalent Capacitance

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From the study of resistive circuits, it is understood that employing a series-parallel combination serves as an effective strategy for simplifying circuits. Capacitors can be arranged within a circuit in one of two ways: a series configuration or a parallel configuration. The way these capacitors are connected to a battery will influence both the potential drop across each individual capacitor and the size of the charge that each capacitor can store. This is determined by the specific type of...
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Th&#233venin Equivalent Circuits01:18

Thévenin Equivalent Circuits

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The household power distribution system, encompassing distribution lines and transformers, serves as the primary network. Electrical appliances within a household can be represented as load impedance. To simplify this intricate distribution system, Thévenin's theorem can be applied to create a Thévenin equivalent circuit. If an AC circuit is partitioned into two parts (circuit A and circuit B), connected by a single pair of terminals as shown in Figure 1.
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Reliability and Validity01:29

Reliability and Validity

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Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
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Related Experiment Video

Updated: Jan 26, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

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Fully Three-Dimensional Bioprinted Skin Equivalent Constructs with Validated Morphology and Barrier Function.

Kristy Derr1, Jinyun Zou2, Keren Luo2

  • 11 Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.

Tissue Engineering. Part C, Methods
|April 23, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel biofabrication method for creating skin tissue equivalents in multiwell plates. This technique offers improved architecture and barrier function for compound testing and disease modeling.

Keywords:
barrier functionbioprintinghigh-throughput screeningkeratinocytesskin

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Area of Science:

  • Tissue engineering
  • Biotechnology
  • Dermatology

Background:

  • Existing biofabrication methods for skin tissue equivalents have limitations.
  • Need for reproducible and scalable models for research and drug development.

Purpose of the Study:

  • To describe a new method for biofabricating skin tissue equivalents in a multiwell plate format.
  • To demonstrate the suitability of this method for functional testing and disease modeling.

Main Methods:

  • Biofabrication of skin tissue equivalents using a multiwell plate system.
  • Assessment of tissue architecture and barrier function.

Main Results:

  • The developed technique overcomes shortcomings of previous engineering methods.
  • Achieved consistent architecture and barrier function across multiple wells.
  • Demonstrated potential for compound functional testing.

Conclusions:

  • The novel biofabrication method provides a robust platform for skin tissue engineering.
  • This approach facilitates the development of disease tissue models for screening applications.
  • Enables more accurate and efficient compound testing and drug development.