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Traumatic optic neuropathy-a contralateral finding: A case report.

Martin Kyncl1,2, Jan Lestak1,3, Jaroslav Tintera1

  • 1JL Clinic, 15800 Prague, Czech Republic.

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|April 23, 2019
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Summary
This summary is machine-generated.

Traumatic optic neuropathy (TON) causes vision loss and alters the contralateral optic tract. This study reveals early retinal ganglion cell and visual pathway changes following unilateral optic nerve injury.

Keywords:
electrophysiological examinationganglion cell complexmagnetic resonance imagingtraumatic lesion of the optic nerve

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neuroimaging

Background:

  • Traumatic optic neuropathy (TON) can lead to significant vision impairment.
  • Understanding the full extent of neural damage in TON is crucial for effective treatment.
  • Contralateral effects following unilateral optic nerve injury are not fully understood.

Purpose of the Study:

  • To investigate visual pathway alterations following traumatic optic neuropathy.
  • To examine the impact of unilateral optic nerve injury on the contralateral visual tract.
  • To explore the initial cellular responses in the retina and visual centers.

Main Methods:

  • Pattern electroretinogram (PERG) and pattern visual-evoked potentials (PVEP) for electrophysiological assessment.
  • Magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) for structural and functional neural evaluation.
  • Assessment of visual acuity in patients with traumatic optic neuropathy.

Main Results:

  • Patients with TON exhibited 50% reduced PERG values in the affected eye and bilateral PVEP abnormalities.
  • MRI confirmed optic nerve atrophy, while fMRI showed decreased visual cortex activity during contralateral eye stimulation.
  • Visual acuity remained at zero in the affected eye post-injury.

Conclusions:

  • Unilateral traumatic optic neuropathy induces contralateral visual tract alterations.
  • Retinal ganglion cells may initially respond to glial activation following injury.
  • These findings suggest a complex, bilateral neural response to unilateral optic nerve trauma.