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Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest

Kai Zimmer1, Florian Kocher1, Gilbert Spizzo1

  • 1Department of Haematology and Oncology, Medical University of Innsbruck, Austria.

Computational and Structural Biotechnology Journal
|April 23, 2019
PubMed

Keywords:
ASCO, American Society of Clinical OncologyAbl, Abelson murine leukemia viral oncogene homolog 1Bcr, Breakpoint cluster regionCGH, Comparative genomic hybridizationCISH, Chromogenic in-situ hybridizationCR, Complete responseDNA, Deoxyribonucleic acidFDA, Food and Drug AdministrationFGFR, Fibroblast growth factor receptorFISH, Fluorescence in-situ hybridizationHER2, Human epidermal growth factor receptor 2HR, Hazard RatioIHC, ImmunohistochemistryMEK, Mitogen-activated protein kinaseMP, Molecular profileMSI, Microsatellite InstabilityMetastatic cancerMolecular profilingNCI, National Cancer InstituteNGS, Next generation sequencingORR, Overall response rateOS, Overall SurvivalPCR, Polymerase chain reactionPFS, Progression-free survivalPIK3CA, Phosphatidylinositol-4,5-bisphosphate-3-kinase catalytic subunit alphaPR, Partial ResponsePTEN, Phosphatase and tensin homologPersonalized medicinePrecision oncologyR/R, Refractory/RelapsedRAF, Rapidly growing fibrosarcoma - proteinRNA, Ribonucleic acidSD, Stable DiseaseTTF, Time to treatment failureWES, Whole-exome sequencingmTOR, Mammalian target of Rapamycin

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