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The genetics and outcomes of an altered FGF23-1,25D-PTH axis in diseases of mineral metabolism.

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Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
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FGF23 Synthesis and Activity.

Megan L Noonan1, Kenneth E White1

  • 1Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

Current Molecular Biology Reports
|April 23, 2019
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor 23 (FGF23) synthesis and actions are influenced by phosphate and vitamin D. Intracellular genes control FGF23 bioactivity, impacting phosphate balance in various diseases.

Keywords:
FAM20CFGF23Fibroblast growth factor-23FurinGALNT3KlothoPSC3PTHosteomalaciaphosphatericketsvitamin D

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Area of Science:

  • Endocrinology
  • Mineral Metabolism
  • Molecular Biology

Background:

  • Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced by osteoblasts/osteocytes.
  • FGF23 production is regulated by serum phosphate and 1,25-dihydroxyvitamin D (1,25D).
  • Recent discoveries of novel FGF23 regulators offer insights into disease pathophysiology.

Purpose of the Study:

  • To review recent studies on FGF23 synthesis and actions.
  • To discuss the role of FGF23 in diseases with altered phosphate balance.

Main Methods:

  • Literature review of recent studies on FGF23.
  • Analysis of FGF23 synthesis, regulation, and signaling pathways.

Main Results:

  • FGF23 synthesis regulation by 1,25D resembles other steroid hormone targets; phosphate response mechanisms are less understood.
  • Intracellular processing genes are critical for FGF23 glycosylation and phosphorylation, determining bioactive FGF23 serum levels.
  • FGF23 actions are primarily mediated by its co-receptor αKlotho (KL), but KL-independent activity exists at high FGF23 concentrations.

Conclusions:

  • Recent advancements enhance understanding of FGF23 synthesis and bioactivity.
  • FGF23 plays a crucial role in maintaining phosphate homeostasis.
  • Further research into FGF23 regulation and signaling is vital for understanding and treating metabolic bone diseases.