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Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
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Improving reperfusion time within the ESCAPE Endovascular Clinical Trial
Noreen Kamal1, Eric E Smith2, Bijoy K Menon3
1Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.
European Stroke Journal
|April 23, 2019
Summary
Fast endovascular treatment for acute ischemic stroke is crucial. The ESCAPE trial used an audit and feedback intervention to significantly reduce treatment times, improving patient outcomes.
Area of Science:
- Neurology
- Interventional Radiology
- Healthcare Quality Improvement
Background:
- Endovascular treatment for acute ischemic stroke is time-sensitive.
- The ESCAPE trial aimed to optimize treatment times.
- Minimizing delays is critical for effective stroke intervention.
Purpose of the Study:
- To describe quality interventions for fast endovascular treatment times.
- To evaluate the effectiveness of an "audit and feedback" intervention.
- To ensure rapid computed tomography-to-reperfusion in stroke patients.
Main Methods:
- Utilized an "audit and feedback" intervention with webinars and letters.
- Monitored computed tomography-to-groin-puncture and computed tomography-to-first-reperfusion times.
- Compared individual site data with overall trial medians.
Main Results:
- Computed tomography-to-groin-puncture time decreased from 57 to 47 minutes.
- Computed tomography-to-first-reperfusion time decreased from 89 to 81 minutes.
- Absolute treatment benefit increased by 7.8% (p < 0.001).
Conclusions:
- "Audit and feedback" is a feasible method to ensure fast treatment times in stroke trials.
- Quality improvement processes are essential for optimal patient selection and outcomes.
- Continued implementation of these processes can enhance stroke care.
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