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Heart rate variability in type 2 diabetic subjects randomized to liraglutide or glimepiride treatment, both in

Thomas Nyström1, Irene Santos-Pardo1, Xin Fang2

  • 1Department of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden.

Endocrinology, Diabetes & Metabolism
|April 23, 2019
PubMed

Insights

Liraglutide increased daytime heart rate (HR) in type 2 diabetes patients, without affecting heart rate variability (HRV) or autonomic nervous system activity. This study compared liraglutide to glimepiride for cardiovascular risk parameters.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Reduced heart rate variability (HRV) and increased heart rate (HR) are linked to cardiovascular mortality.
  • The Liraglutide Effect and Action in Diabetes trial showed fewer cardiovascular events with liraglutide in type 2 diabetes (T2D) patients.

Purpose of the Study:

  • To compare the effects of liraglutide versus glimepiride on HR and HRV in T2D patients.
  • To assess liraglutide's impact on cardiovascular risk parameters.

Main Methods:

  • A post hoc study involving 62 T2D patients randomized to liraglutide or glimepiride, both with metformin.
  • 24-hour Holter monitoring assessed HR, sympathetic activity (SDNN), and parasympathetic activity (RMSSD, HF, LF power).

Main Results:

  • Liraglutide treatment led to a persistent increase in diurnal HR and a significant increase in daytime HR (5.4 bpm, P=0.011).
  • No significant differences were observed between groups in SDNN, RMSSD, HF, or LF power.

Conclusions:

  • Liraglutide increased diurnal HR variation and mean daytime HR.
  • These HR changes occurred independently of alterations in sympathetic or parasympathetic activity.
Abstract

Keywords:
automatic nervous systemcardiac autonomic neuropathyglimepirideheart rate variabilityliraglutidetype 2 diabetes mellitus

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