[Molecular mechanism of vascular remodeling in hypertension and Chinese medicine intervention]

Area of Science:

• Cardiovascular Science
• Pathophysiology
• Pharmacology

Background:

• Vascular remodeling is a hallmark of hypertension, initially adaptive but ultimately maladaptive.
• This process compromises target organ function, leading to cardiovascular complications.
• Complex regulatory networks govern vascular remodeling in hypertension.

Purpose of the Study:

• To review the role and mechanisms of vascular remodeling in hypertension pathogenesis and progression.
• To explore traditional Chinese medicine (TCM) strategies for treating hypertensive vascular remodeling.
• To identify potential therapeutic targets and active TCM ingredients for vascular protection.

Main Methods:

• Literature review focusing on vascular remodeling in hypertension.
• Analysis of signaling pathways involved in hypertensive vascular remodeling.
• Examination of TCM syndrome differentiation for therapeutic applications.

Main Results:

• Vascular remodeling contributes significantly to hypertension and its complications.
• TCM offers evidence-based strategies for managing hypertensive vascular remodeling.
• Understanding molecular mechanisms can guide novel therapeutic approaches.

Conclusions:

• Vascular remodeling is a critical target for managing hypertension and preventing cardiovascular disease.
• TCM provides a valuable framework for developing new therapies.
• Further research into signaling pathways and TCM compounds is warranted for effective vascular protection.