Related Experiment Video

Updated: Jan 26, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

8.1K

[Advances on the anti-inflammatory and protective effect of AMPK activators]

Xian-Wen Peng1, Hong-Hong Zhou1, Jie Dai2

  • 1Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|April 23, 2019
PubMed

Insights

AMP-activated protein kinase (AMPK) activators show protective effects against inflammatory diseases. These compounds offer potential therapeutic strategies for conditions like acute lung injury and colitis.

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Immunology

Background:

  • AMP-activated protein kinase (AMPK) regulates cellular energy.
  • Emerging evidence highlights AMPK's role in modulating inflammation.
  • Inflammation is an energy-demanding biological process.

Purpose of the Study:

  • To review the role of AMPK activators in inflammatory diseases.
  • To explore the therapeutic potential of AMPK activators.

Main Methods:

  • Literature review of studies on AMPK activators and inflammation.
  • Analysis of common AMPK activators: AICAR, A-769662, metformin, and adiponectin.
  • Examination of animal models for various inflammatory conditions.

Main Results:

  • AMPK activators demonstrate protective effects in models of acute lung injury, asthma, colitis, hepatitis, and atherosclerosis.
  • Metformin and adiponectin's biological activities are linked to AMPK activation.
  • AICAR and A-769662 are commonly used AMPK activators.

Conclusions:

  • AMPK activators exhibit significant potential in managing inflammatory responses.
  • These findings suggest promising therapeutic applications for AMPK activators in treating inflammatory diseases.

More Related Videos

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

1.0K
Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

8.9K

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.2K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.6K
Zones of Protection01:16

Zones of Protection

In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
785
Protection of Alcohols02:31

Protection of Alcohols

This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.0K
Protecting Self-Esteem01:27

Protecting Self-Esteem

Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
204
Radial System Protection01:23

Radial System Protection

Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
431