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Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Autologous Platelet-Rich Plasma and Fibrin Glue Decrease Pain Following Excision and Primary Closure of Pilonidal
Daryoush Hamidi Alamdari1, Mohamad Reza Motie, Nasim Kamalahmadi
1In the Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Daryoush Hamidi Alamdari, PhD, is Associate Professor of Biochemistry; Mohamad Reza Motie, MD, is Associate Professor of Surgery; Nasim Kamalahmadi, MD, is a Medical Practitioner; and Mohsen Aliakbarian, MD, is Associate Professor of Surgery. Acknowledgments: The authors thank the patients who participated in the study and Ms M. Hassanpour for editing the manuscript. The study was supported by the Vice Chancellor for Research of Mashhad University of Medical Sciences (grant 88529). The authors have disclosed no other financial relationships related to this article. Submitted April 24, 2018; accepted in revised form June 8, 2018.
Autologous platelet-rich plasma and fibrin glue (PRP-FG) significantly reduced post-surgical pain for pilonidal sinus patients. This treatment shows potential for improving recovery after excisional surgery with primary closure.
Area of Science:
- Wound Healing
- Regenerative Medicine
- Surgical Innovation
Background:
- Pilonidal sinus is a complex chronic wound affecting the natal clefts, frequently requiring surgical intervention.
- This condition commonly impacts younger adults, leading to significant disability.
Purpose of the Study:
- To evaluate the efficacy of autologous platelet-rich plasma and fibrin glue (PRP-FG) in managing pain and promoting healing.
- To assess the impact of PRP-FG on the recovery process following pilonidal sinus excisional surgery with primary closure.
Main Methods:
- A randomized clinical trial involving 40 patients with pilonidal sinus.
- Patients were divided into a control group (excision with primary closure) and a case group (excision with primary closure plus PRP-FG injection).
- Outcomes including pain severity, healing time, return to normal activities, infection, and recurrence were monitored for 6 months.
Main Results:
- Significant pain reduction was observed in the PRP-FG group during the first two weeks post-surgery compared to the control group.
- While healing time showed a decrease in the case group, this difference was not statistically significant.
- No significant differences were found between the groups regarding infection rates or recurrence of the pilonidal sinus.
Conclusions:
- Autologous platelet-rich plasma and fibrin glue (PRP-FG) demonstrates significant potential for pain reduction in patients undergoing primary closure for pilonidal sinus.
- PRP-FG may offer adjunctive benefits in the post-operative management of pilonidal sinus surgery.
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