Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

5.3K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
5.3K
Structural Protein Function01:56

Structural Protein Function

29.9K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
29.9K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

345
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
345
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.1K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.1K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

1.7K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.7K
Relationship Formation02:12

Relationship Formation

45.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
45.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Prefrontal engrams of long-term fear memory perpetuate pain perception.

Nature neuroscience·2026
Same author

Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics.

Cell reports. Medicine·2026
Same author

Cancer neuroscience: The past, the present, and the road ahead.

Cell·2026
Same author

Recommendations for the inclusion and study of sex and gender in research.

Nature neuroscience·2025
Same author

Iron biomarkers predict peripheral artery disease in females.

Atherosclerosis·2025
Same author

Corrigendum to "CD248 induces a maladaptive unfolded protein response in diabetic kidney disease." Kidney International 2023;103:304-319.

Kidney international·2024

Related Experiment Video

Updated: Jan 26, 2026

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.3K

Structure-function relationships in peripheral nerve contributions to diabetic peripheral neuropathy.

Tessa Frank1, Peter Nawroth2, Rohini Kuner1

  • 1Department of Molecular Pharmacology, Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.

Pain
|April 23, 2019
PubMed
Summary

Diabetic peripheral neuropathy (DPN) causes pain in half of diabetes mellitus patients. Understanding sensory neuron changes in mouse models is key to developing new DPN treatments.

More Related Videos

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
11:29

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

Published on: January 3, 2011

27.3K
Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

3.3K

Related Experiment Videos

Last Updated: Jan 26, 2026

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.3K
Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
11:29

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

Published on: January 3, 2011

27.3K
Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

3.3K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pathology

Background:

  • Diabetes mellitus (DM) affects over 9% of the global population.
  • Diabetic peripheral neuropathy (DPN) is a common DM complication, causing neuropathic pain in up to 50% of patients.
  • Current treatments and prevention strategies for DPN are insufficient, highlighting a critical unmet medical need.

Purpose of the Study:

  • To review commonly used mouse models for DPN induced by type 1 and type 2 DM.
  • To discuss structural alterations in Aβ, Aδ, and C fibers during DPN progression.
  • To explore the functional contributions of these fiber changes to painful DPN in humans and animal models.

Main Methods:

  • Review of existing literature on DPN mouse models.
  • Analysis of structural changes in different sensory fiber types (Aβ, Aδ, C).
  • Examination of structure-function relationships in painful DPN.

Main Results:

  • Mouse models of type 1 and type 2 DM exhibit structural changes in sensory fibers relevant to DPN.
  • Specific structural alterations in Aβ, Aδ, and C fibers correlate with neuropathic pain.
  • Understanding these structure-function relationships is crucial for therapeutic development.

Conclusions:

  • Mouse models are essential for studying the complex mechanisms of DPN.
  • Further research into sensory neuron structure-function dynamics is needed.
  • Technological advances can aid in developing targeted therapeutics for painful DPN.