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Updated: Jan 26, 2026
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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
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Epigenome-wide association studies in asthma: A systematic review
Ahmed Edris1, Herman T den Dekker2,3,4, Erik Melén5,6,7
1Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Summary
Epigenome-wide association studies (EWAS) reveal numerous differentially methylated sites linked to asthma. Further research with larger sample sizes is crucial to understand epigenetic factors in asthma
Area of Science:
- Genetics and Genomics
- Environmental Health
- Respiratory Medicine
Background:
- Asthma is a chronic respiratory disease influenced by environmental factors and genetic interactions.
- Epigenetic changes, particularly DNA methylation, are implicated in asthma development.
- Epigenome-wide association studies (EWAS) investigate the link between DNA methylation and asthma.
Purpose of the Study:
- To systematically review and identify all human EWAS assessing differentially methylated sites associated with asthma.
- To synthesize findings on DNA methylation patterns in asthma across different populations and sample types.
Main Methods:
- Systematic literature search of PubMed and Embase databases (2005-2019).
- Inclusion of EWAS studies investigating differential methylation in asthma.
- Bias assessment using the Newcastle-Ottawa Scale for cohort studies.
Main Results:
- Sixteen EWAS studies were identified, with a majority focusing on children and smaller sample sizes.
- Thousands of differentially methylated sites were found in adults, and 419 CpGs in children.
- Differential methylation in inflammatory genes correlated with gene expression, with specific genes like SMAD3, IL13, and TIGIT identified.
Conclusions:
- EWAS have identified numerous differentially methylated CpGs in asthma-related genes.
- Larger sample sizes and analysis of diverse asthma phenotypes are needed.
- Further research is essential to evaluate the role of epigenetics in asthma pathophysiology and clinical applications.
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