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Association Between miR-155, Its Polymorphism and Ischemia-Modified Albumin in Patients with Rheumatoid Arthritis

Olfat G Shaker1, Omayma O Abdelaleem2, Nermeen A Fouad3

  • 11 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|April 23, 2019
PubMed

Insights

MicroRNA-155 (miR-155) and ischemia-modified albumin (IMA) are elevated in rheumatoid arthritis (RA) patients. miR-155 and its genetic variant rs767649 are linked to RA risk and severity.

Area of Science:

  • Immunology
  • Genetics
  • Biochemistry

Background:

  • Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease.
  • Understanding the molecular mechanisms underlying RA pathogenesis is crucial for developing effective treatments.
  • Biomarkers for RA risk and progression are actively sought.

Purpose of the Study:

  • To quantify serum miR-155 levels and the miR-155 (rs767649) genetic variant in RA patients.
  • To assess the association between miR-155, its genetic variant, and ischemia-modified albumin (IMA) in RA.
  • To explore the potential role of miR-155 as a therapeutic target in RA.

Main Methods:

  • Quantitative real-time polymerase chain reaction (qPCR) for miR-155 expression and rs767649 genotyping.
  • Enzyme-linked immunosorbent assay (ELISA) for measuring IMA levels.
  • Comparative analysis between 79 RA patients and 78 healthy controls.

Main Results:

  • RA patients exhibited significantly higher miR-155 expression and IMA levels compared to controls (P < 0.0001).
  • miR-155 fold change positively correlated with IMA levels (r=0.362, P=0.001) in RA patients.
  • Significant differences in miR-155 (rs767649) genotype and allele frequencies were observed between RA patients and controls, with higher levels in the TT genotype.

Conclusions:

  • miR-155 and its variant rs767649 may contribute to RA susceptibility and increased risk.
  • IMA levels are elevated in RA and correlate with miR-155 and its genetic variant.
  • miR-155 represents a potential therapeutic target for rheumatoid arthritis treatment.
Keywords:
Egyptian patientsischemia-modified albuminmiR-155micro-RNApolymorphismrheumatoid arthritis

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