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Updated: Jan 26, 2026
09:29
Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
Published on: October 11, 2017
12.1K
Lesion Localization of Poststroke Lateropulsion.
Suzanne R Babyar1,2, Anna Smeragliuolo3, Fatimah M Albazron4
1From the Department of Physical Therapy, Hunter College, The City University of New York, NY (S.R.B.).
Stroke
|April 23, 2019
Summary
Lateropulsion, or pusher syndrome after stroke, is linked to brain lesions in the inferior parietal lobe. This finding may improve rehabilitation strategies for stroke survivors with this condition.
Area of Science:
- Neuroscience
- Neurology
- Rehabilitation Medicine
Background:
- Previous studies on lateropulsion (pusher syndrome) and brain lesions after stroke yielded inconsistent results.
- Small, unmatched samples limited the ability to pinpoint specific brain regions associated with lateropulsion.
Purpose of the Study:
- To determine if lateropulsion in stroke patients localizes to specific brain regions.
- To utilize a case-control design for robust analysis of lesion-symptom relationships.
Main Methods:
- Matched 50 patients with lateropulsion to 50 without, controlling for age, stroke onset, motor FIM, lesion side, and gender.
- Employed multivariate lesion symptom mapping with sparse canonical correlations.
- Assessed lateropulsion using the Burke Lateropulsion Scale.
Main Results:
- Lesion symptom mapping identified the inferior parietal lobe (Brodmann Areas 2 and 40) as the region most associated with lateropulsion.
- Patients with lateropulsion had significantly larger lesion volumes.
- Group-level differences in motor performance and total Functional Independence Measure (FIM) scores were observed despite matching.
Conclusions:
- Inferior parietal lobe lesion involvement is a key neuroanatomical determinant for developing lateropulsion.
- Understanding these anatomical underpinnings can enhance stroke rehabilitation.
- Findings may inform the development of noninvasive neuromodulation techniques for pusher syndrome.
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