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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Microcatheter Aspiration Thrombectomy with a 0.025″ Microcatheter for Distal Vessel Occlusions in Acute Ischemic Stroke with Disabling Deficits.

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Related Experiment Video

Updated: Jan 26, 2026

Quantifying Branching Density in Rat Mammary Gland Whole-mounts Using the Sholl Analysis Method
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ERASER.

Jens Fiehler1, Goetz Thomalla2, Martina Bernhardt1

  • 1From the Department of Neuroradiology (J.F., M.B., H.K., S.G.), University Hospital Hamburg-Eppendorf, Germany.

Stroke
|April 23, 2019
PubMed
Summary

Next-generation mechanical thrombectomy devices significantly reduced infarct volume compared to predictions from intravenous thrombolysis alone in ischemic stroke patients. This novel approach demonstrated a high rate of good clinical outcomes, highlighting its potential in neurovascular treatment.

Keywords:
Germanybraininfarctionpatientsthrombectomy

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Area of Science:

  • Neuroscience
  • Medical Technology
  • Stroke Research

Background:

  • Ischemic stroke treatment relies on timely reperfusion.
  • Mechanical thrombectomy devices are evolving for improved efficacy.
  • Comparing new devices to existing therapies requires innovative study designs.

Purpose of the Study:

  • To evaluate the effectiveness of next-generation mechanical thrombectomy devices in ischemic stroke.
  • To compare outcomes against virtual comparators derived from predictive modeling.
  • To test the hypothesis that mechanical thrombectomy is superior to intravenous thrombolysis alone.

Main Methods:

  • The ERASER study utilized a prospective, multicenter, single-arm design with virtual 2-arm comparisons.
  • Effectiveness was assessed using a novel recanalization device and intermediate catheter.
  • The primary endpoint was the volume of saved brain tissue, calculated using a machine learning model.

Main Results:

  • Eighty-one patients with internal carotid artery or middle cerebral artery occlusions were enrolled.
  • The median volume of saved tissue was 50 mL (P<0.0001), indicating smaller infarcts than predicted.
  • A good clinical outcome (modified Rankin Scale 0-2) was achieved in 70% of patients, with a 95% recanalization rate.

Conclusions:

  • The ERASER study successfully employed predictive analytics for intraindividual virtual comparisons in mechanical thrombectomy.
  • Next-generation thrombectomy devices demonstrated superior efficacy in reducing infarct volume compared to intravenous thrombolysis alone.
  • The novel study design shows promise for future neurovascular research and clinical trials.