Increased susceptibility to pertussis in adults at childbearing age as determined by comparative seroprevalence study, China 2010-2016

This study was aimed to determine pertussis specific serum PT-IgG antibodies in healthy individuals during 2010 and 2015/2016 in Beijing, China.

A total of 3884 healthy individuals were included: 3058 aged 3-69 years randomly selected from an epidemiological survey conducted in 2010, and 826 aged 20-39 years selected from those who attended an annual medical examination in 2015/2016. Serum PT-IgG antibodies were determined using the Serion/Virion ELISA kits.

Of 3058 subjects in 2010, 167 (5.5%) and 39 (1.3%) subjects had PT-IgG antibodies ≥40 IU/ml and ≥100 IU/ml, respectively. No differences were observed among different age groups. Altogether, 26.2% had undetectable PT-IgG antibodies (<5 IU/ml), and the highest undetectable rate of 56.8% was found in children aged 3-5 years. When the age group of 20-39 years was compared between the two periods, no difference was found in seroprevalence of PT-IgG antibodies ≥ 40 IU/ml (5.1% vs. 4.0%). However, an undetectable rate of PT-IgG antibodies was significantly higher in 2015/2016 than that in 2010 (57.4% vs. 29.1%, p < 0.001).

Our results showed that about 5% of individuals had PT-IgG antibodies indicative of a recent infection, and adults at childbearing age have an increased risk to pertussis in China.