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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Effective encapsulation of curcumin in nanoparticles enabled by hydrogen bonding using flash nanocomplexation

Xiyu Ke1, Haoyu Tang2, Hai-Quan Mao3

  • 1Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA; Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.

International Journal of Pharmaceutics
|April 23, 2019
PubMed
Summary

Flash nanocomplexation (FNC) offers a scalable method to create curcumin nanoparticles for drug delivery. Lower drug loading in these nanoparticles enhanced cellular uptake and cytotoxicity in prostate cancer cells.

Keywords:
CurcuminDrug loadingFlash nanocomplexation (FNC)Hydrogen bonding interactionsNanoparticles

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