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Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos
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Evaluation of Phage Therapy in the Context of Enterococcus faecalis and Its Associated Diseases

Andrei S Bolocan1,2, Aditya Upadrasta3,4, Pedro H de Almeida Bettio5,6

  • 1APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland. andrei.s.bolocan@gmail.com.

Viruses
|April 24, 2019
PubMed

Insights

Bacteriophages (phages) show promise as natural antimicrobial agents against antibiotic-resistant Enterococcus faecalis infections. This review explores phage efficacy, genomic analysis, and safety for potential phage therapy applications.

Area of Science:

  • Microbiology
  • Virology
  • Infectious Diseases

Background:

  • Enterococcus faecalis is a common bacterium that can cause severe infections in immunocompromised individuals.
  • Antibiotic resistance in E. faecalis necessitates alternative therapeutic strategies.
  • Bacteriophages (phages) are viruses that infect bacteria and are being explored as antimicrobial agents.

Purpose of the Study:

  • To review the efficacy of bacteriophages in controlling Enterococcus faecalis infections.
  • To analyze the genomes of E. faecalis phages for therapeutic potential.
  • To assess the safety of phages for clinical application.

Main Methods:

  • Literature review of in vitro and in vivo studies on E. faecalis phages.
  • Genomic comparison of E. faecalis phages using orthocluster analysis.
  • Examination of E. faecalis phages for antibiotic-resistant genes and endolysin domain architecture.

Main Results:

  • Accumulated evidence supports the efficacy of phage therapy against E. faecalis infections.
  • Genomic analysis helps categorize phages for therapeutic suitability.
  • Assessment of antibiotic-resistant genes and endolysins ensures phage safety for clinical use.

Conclusions:

  • Bacteriophages represent a viable therapeutic option for E. faecalis infections.
  • Further research and development are needed for commercial phage cocktails.
  • Phage therapy holds potential for combating antibiotic-resistant bacterial infections.
Keywords:
E. faecalisOrthoMCLphage therapy

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