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Intracellular uptake of EGCG-loaded deformable controlled release liposomes for skin cancer

M Marwah1, Y Perrie2, R K S Badhan3

  • 1School of Life and Health Sciences, Aston University, Birmingham, UK.

Journal of Liposome Research
|April 24, 2019
PubMed

Insights

This study developed deformable liposomes using Tween 20 for enhanced skin cancer treatment delivery. These liposomes improved drug release and cellular penetration, offering a promising new approach for dermal drug delivery.

Area of Science:

  • Pharmaceutical Sciences
  • Dermatology
  • Nanotechnology

Background:

  • Caucasian populations have a higher risk of skin cancer.
  • Current treatments for skin cancer have limitations in efficacy and toxicity.
  • There is a need for improved drug delivery systems for dermal applications.

Purpose of the Study:

  • To develop a deformable liposomal formulation for dermal delivery of epigallocatechin gallate (EGCG).
  • To investigate the effect of Tween 20 on liposome properties and EGCG release.
  • To assess the intracellular localization of deformable liposomes in dermal cells.

Main Methods:

  • Formulation of deformable liposomes with varying concentrations of Tween 20.
  • Characterization of liposome deformability and elasticity.
  • In vitro release studies of EGCG from liposomes over 24 hours.
  • Confocal microscopy to visualize intracellular delivery of DilC-loaded liposomes in human dermal fibroblasts and keratinocytes.

Main Results:

  • Increased Tween 20 concentration significantly decreased liposome deformability index, enhancing elasticity.
  • Tween 20 incorporation markedly increased EGCG release over 24 hours.
  • Deformable liposomes were successfully localized intracellularly within dermal cells within 2 hours.

Conclusions:

  • Deformable liposomes formulated with Tween 20 demonstrate enhanced drug release and improved dermal cellular penetration.
  • This formulation holds potential for developing effective controlled-release topical treatments for skin conditions.
  • The findings suggest a promising strategy for overcoming limitations of conventional dermal drug delivery.
Keywords:
Skin cancercontrolled releasedeformable liposomesdermal releaseelastic liposomes

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