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Myocardial Infarction and Functional Outcome Assessment in Pigs
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Accurate assessment of LV function using the first automated 2D-border detection algorithm for small animals -
Jana Grune1,2, Daniel Ritter2,3, Kristin Kräker2,4,5,6,7
1Institute of Physiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Cardiovascular Ultrasound
|April 24, 2019
Summary
A new automated echocardiography software (Auto2DE) offers faster cardiac function assessment in small animals. While accurate with good image quality, its performance varies with specific cardiac pathologies.
Area of Science:
- Cardiology
- Veterinary Medicine
- Medical Imaging
Background:
- Echocardiography is crucial for non-invasive cardiac function assessment in small animals.
- Manual analysis of echocardiograms is time-consuming and operator-dependent.
Purpose of the Study:
- To evaluate a novel automated 2D echocardiography software (Auto2DE) for small animal cardiac function analysis.
- To compare the accuracy and efficiency of Auto2DE against manual 2D echocardiography (2DE).
Main Methods:
- Validation of Auto2DE using mouse and rat cine loops, stratified by image quality.
- Comparison of Auto2DE and 2DE in mouse and rat models with various cardiac pathologies.
Main Results:
- Automated assessment (Auto2DE) was faster and operator-independent compared to manual 2DE.
- Auto2DE accuracy in healthy mice correlated with image quality, showing excellent agreement in adequate quality loops.
- Auto2DE detected impaired cardiac function in models with pronounced phenotypes but performed poorly in diabetic models.
Conclusions:
- Auto2DE provides rapid LV function assessment suitable for studies with high-quality echocardiographic images.
- The software has limitations in specific pathologies and is sensitive to image quality, requiring careful consideration in research applications.
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