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Elevated serum concentrations of DNAJB9 in fibrillary glomerulonephritis: another step toward understanding

Nicole K Andeen1

  • 1Department of Pathology, Oregon Health & Science University, Portland, Oregon, USA.

Kidney International
|April 24, 2019
PubMed

Insights

DnaJ homolog subfamily B member 9 (DNAJB9) shows promise as a biomarker for fibrillary glomerulonephritis (FGN). Elevated DNAJB9 serum concentrations were found in FGN patients, suggesting potential for non-invasive diagnosis.

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Glomerular Diseases

Background:

  • Fibrillary glomerulonephritis (FGN) is a rare kidney disease.
  • Diagnosis often relies on invasive kidney biopsies.
  • Identifying reliable biomarkers is crucial for FGN management.

Purpose of the Study:

  • To investigate DnaJ homolog subfamily B member 9 (DNAJB9) as a potential serum biomarker for FGN.
  • To assess the diagnostic utility of serum DNAJB9 concentrations in FGN patients.

Main Methods:

  • Serum samples from FGN patients and controls were analyzed.
  • Concentrations of DNAJB9 were measured in these samples.

Main Results:

  • Significantly elevated serum concentrations of DNAJB9 were observed in patients with FGN compared to controls.
  • DNAJB9 demonstrates high sensitivity and specificity as a marker in kidney biopsies.

Conclusions:

  • Serum DNAJB9 is a promising, sensitive, and specific biomarker for FGN.
  • This finding supports potential clinical applications for non-invasive FGN diagnosis and monitoring.

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