Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO)

Alfred K Cheung1, Tara I Chang2, William C Cushman3

  • 1Division of Nephrology & Hypertension, University of Utah, Salt Lake City, Utah, USA.

Kidney International
|April 24, 2019
PubMed

Insights

Kidney Disease: Improving Global Outcomes (KDIGO) experts reviewed blood pressure (BP) management in chronic kidney disease (CKD). New evidence from clinical trials prompted reevaluation of 2012 guidelines for CKD patients not on dialysis.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Practice Guidelines

Background:

  • The 2012 KDIGO Guideline provides recommendations for blood pressure (BP) management in chronic kidney disease (CKD).
  • New clinical trial evidence has emerged since the 2012 guideline publication.
  • Optimal BP measurement and management strategies in CKD require ongoing evaluation.

Purpose of the Study:

  • To reassess KDIGO's 2012 clinical practice guidelines for BP management in CKD.
  • To evaluate new evidence from recent clinical trials relevant to BP in CKD.
  • To discuss optimal methods for BP measurement and management in CKD patients.

Main Methods:

  • Convened a multidisciplinary panel of clinical and scientific experts.
  • Focused discussions on evidence from recent clinical trials.
  • Reviewed existing KDIGO guidelines and new data.

Main Results:

  • The conference identified areas for potential guideline reevaluation based on new evidence.
  • Discussions highlighted the importance of optimal BP measurement techniques.
  • Consensus was reached on excluding BP management in patients on maintenance dialysis from the scope.

Conclusions:

  • New evidence necessitates a review of the 2012 KDIGO BP management guidelines for CKD.
  • Optimal BP measurement and management strategies remain critical areas of focus for CKD care.
  • The conference recommendations will inform future updates to CKD guidelines.

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
613
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
601
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
377
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
342
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.1K
Blood and Nerve Supply to the Kidney01:18

Blood and Nerve Supply to the Kidney

The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of...
4.3K