Related Experiment Video
Updated: Jan 26, 2026

Protein Engineering by Yeast Surface Display
Published on: November 29, 2024
Protein Chimerization: A New Frontier for Engineering Protein Therapeutics with Improved Pharmacokinetics
A R Satvik Iyengar1, Shreya Gupta1, Snehal Jawalekar1
1Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India.
Abstract:
With the advancement of medicine, the utility of protein therapeutics is increasing exponentially. However, a significant number of protein therapeutics suffer from grave limitations, which include their subpar pharmacokinetics. In this study, we have reviewed the emerging field of protein chimerization for improving the short circulatory half-life of protein therapeutics. We have discussed various aspects of protein therapeutics aiming at their mechanism of clearance and various approaches used to increase their short circulatory half-life with principal focus on the concept of chimerization. Furthermore, we have comprehensively reviewed various components of chimera, such as half-life extension partners and linkers, their shortcomings, and prospective work to be undertaken for developing effective chimeric protein therapeutics.
Related Concept Videos
Physiological Pharmacokinetic Models: Assumption with Protein Binding
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
Protein-protein Interfaces
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme...
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
What are Proteins?

