Oral Drug Delivery Technologies-A Decade of Developments

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery
• Medicinal Chemistry

Background:

• Advanced drug delivery technologies facilitate drug reformulation and new administration routes, supporting life-cycle management.
• There's a growing trend towards using delivery technologies for drug repurposing, addressing solubility, permeability, safety, and efficacy challenges.
• The oral route is highly preferred for its compliance and safety, especially for chronic conditions like pain.

Purpose of the Study:

• To review advances in oral drug delivery technologies.
• To explore applications for transforming injectable drugs to oral formulations.
• To enhance risk-benefit profiles of existing oral drugs and minimize drug attrition in early discovery.

Main Methods:

• Literature review of advanced oral drug delivery technologies.
• Analysis of case studies on injectable-to-oral transformation.
• Evaluation of technologies for improving oral drug efficacy and safety.

Main Results:

• Oral delivery technologies offer solutions for solubility and permeability issues.
• These technologies can improve the safety and efficacy profiles of existing drugs.
• Application in early discovery can reduce drug attrition rates.

Conclusions:

• Advanced oral delivery technologies are crucial for drug repurposing and life-cycle management.
• Transforming injectables to oral formulations enhances patient compliance and safety.
• Integrating these technologies early in drug discovery can significantly reduce attrition rates.