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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Overview of Advanced Functional Groups02:22

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The two main cell...
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Group Therapy01:26

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies
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Biomanufacturing for clinically advanced cell therapies.

Ayesha Aijaz1, Matthew Li2, David Smith3

  • 1Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA.

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|April 24, 2019
PubMed
Summary
This summary is machine-generated.

Advancing cell therapies to market requires robust biomanufacturing. This review highlights innovative bioprocessing technologies to overcome production challenges for clinical cell therapies.

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Area of Science:

  • Biotechnology
  • Cell Therapy Manufacturing
  • Bioprocessing

Background:

  • Cell-based therapeutics show significant promise, driving market entry efforts.
  • Clinical advancements in cell therapies, such as chimeric antigen receptor T-cell immunotherapy and engineered haematopoietic stem cells, generate large datasets.
  • Scaling up cell therapy production necessitates addressing limitations in harvesting, expansion, manipulation, purification, preservation, and formulation.

Purpose of the Study:

  • To emphasize the critical biomanufacturing requirements for clinical and commercial-scale cell therapy production.
  • To review cutting-edge bioprocessing technologies that enhance the efficiency of cell therapy manufacturing.
  • To provide case examples of technologies applicable to cell therapies nearing clinical use.

Main Methods:

  • Review of current literature and case studies on cell therapy biomanufacturing.
  • Identification and analysis of innovative bioprocessing technologies.
  • Focus on technologies addressing limitations in the cell therapy production workflow.

Main Results:

  • Biomanufacturing efficiency is a key bottleneck for cell therapy commercialization.
  • Several advanced bioprocessing technologies can improve cell harvesting, expansion, manipulation, purification, preservation, and formulation.
  • Successful implementation of these technologies can lead to cost-effective and efficient production of cell therapies.

Conclusions:

  • Optimizing biomanufacturing infrastructure is essential for the successful clinical translation and commercialization of cell therapies.
  • Adoption of cutting-edge bioprocessing technologies is crucial for meeting the demands of large-scale cell therapy production.
  • Addressing current limitations in cell therapy manufacturing will enable wider patient access to these transformative treatments.