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Updated: Jan 26, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Significance of Complement System in Ischemic Stroke: A Comprehensive Review
Yuanyuan Ma1,2, Yanqun Liu3, Zhijun Zhang2
11Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Aging and Disease
|April 24, 2019
Summary
The complement system aids immunity but can worsen brain injury after stroke. Inhibiting it shows promise for stroke treatment, but challenges remain in clinical application.
Area of Science:
- Neuroscience
- Immunology
- Pathology
Background:
- The complement system, crucial for innate immunity, paradoxically contributes to damage in ischemic brain injury.
- While complement activation exacerbates stroke pathology, its inhibition faces clinical limitations and potential side effects due to its role in neural repair.
Purpose of the Study:
- To review the dual role of complement components (e.g., C3a, C5a) in normal brain function and ischemic stroke pathophysiology.
- To comprehensively assess current complement-targeted therapies for ischemic stroke and their clinical translation challenges.
Main Methods:
- Literature review of complement system's role in cerebral ischemia.
- Analysis of current therapeutic strategies and clinical development of complement inhibitors for stroke.
Main Results:
- The complement system significantly impacts both the injury and recovery phases of ischemic stroke.
- Existing complement inhibitors show therapeutic potential but face hurdles in clinical availability and systemic side effects.
Conclusions:
- Targeting the complement system offers a promising avenue for ischemic stroke treatment.
- Further research into the precise mechanisms of complement components in different stroke stages is essential for optimizing therapeutic interventions.
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