Related Experiment Video
Updated: Jan 26, 2026

Author Spotlight: Advances in Brain Energy Metabolism Research Using the Drosophila Model
Published on: October 27, 2023
Dynamics of in Vivo Metabolites Concentrations in Posttraumatic Period of Human Brain. 1H MRS Study
N A Semenova1,2,3, P E Menshchikov1,2,3, A V Manzhurtsev4,5
1Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia.
Abstract:
For the first time the intracellular concentrations of N-acetylaspartate (NAA), aspartate (Asp), and glutamate (Glu) were measured in human brain in vivo, and the effect of severe traumatic brain injury on NAA synthesis in acute and remote posttraumatic phases was revealed. In non-damaged (MRI-negative) lobes the next day after injury, Asp and Glu decreased by 45% and 35%, respectively, while NAA decreased only by 16%. A negative correlation between NAA and Asp/Glu ratio was found. The Glu level returned to the norm long after injury, Asp remained below the norm by 60%, NAA decreased by 65% relative to the norm, and Asp/Glu decreased significantly. The results obtained educe the leading role of neuronal aspartate-malate shuttle in NAA synthesis alterations.
Related Concept Videos
The Periodic Table
Periodic Classification of the Elements
The Periodic Table and Organismal Elements
Effective Value of a Periodic Waveform
The effective value of a periodic current represents the direct current (DC) that conveys the same average power to a resistor as the periodic current itself. This concept is crucial when assessing AC circuits. To determine the...
Concentration Cells
Consider the following voltaic cell:
Dynamic Equilibrium

