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3D Bioprinting in Skeletal Muscle Tissue Engineering
Serge Ostrovidov1, Sahar Salehi2, Marco Costantini3
1Center for Minimally Invasive Therapeutics (C-MIT), Department of Radiological Sciences, University of California, Los Angeles, CA, 90095, USA.
Small (Weinheim an Der Bergstrasse, Germany)
|April 24, 2019
Summary
Skeletal muscle tissue engineering (SMTE) faces challenges in replicating muscle complexity. 3D bioprinting offers a promising new fabrication tool to advance SMTE for better muscle repair solutions.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Tissue Engineering
Background:
- Skeletal muscle tissue engineering (SMTE) seeks to repair damaged muscles.
- Current fabrication methods struggle to replicate the intricate structure of skeletal muscle.
- Conventional SMTE approaches have limitations in achieving functional muscle regeneration.
Purpose of the Study:
- To review the current state of skeletal muscle tissue engineering.
- To highlight the potential of 3D bioprinting as an advanced fabrication tool for SMTE.
- To provide an overview of bioinks and methods used in 3D bioprinting for muscle regeneration.
Main Methods:
- Review of conventional skeletal muscle tissue engineering techniques.
- Discussion of current 3D bioprinting technologies applicable to SMTE.
- Analysis of bioink formulations, properties, and their role in 3D bioprinting for muscle constructs.
Main Results:
- 3D bioprinting presents novel strategies to overcome limitations of conventional SMTE.
- Specific bioinks and printing parameters are crucial for fabricating functional muscle tissues.
- Recent advances demonstrate the capability of 3D bioprinting in creating complex muscle structures.
Conclusions:
- 3D bioprinting is a transformative technology for skeletal muscle tissue engineering.
- Further research is needed to optimize bioinks and printing processes for clinical translation.
- Future perspectives indicate significant potential for 3D bioprinting in achieving effective muscle repair.
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