Related Experiment Video

Updated: Jan 26, 2026

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

14.7K

Nandrolone decanoate and resistance exercise affect prostate morphology and hormone receptor interface in adult rats

F de C Gomes1,2, L G de A Chuffa1, W J Fávaro3

  • 1Department of Anatomy, Institute of Biosciences, University of Estadual Paulista (UNESP), Botucatu, SP, Brazil.

Andrology
|April 24, 2019
PubMed
Abstract

Insights

Nandrolone decanoate (ND) use, with or without resistance exercise (RE), alters sex hormones and prostate morphology in adult and aged rats. These findings highlight potential risks of ND, even when combined with exercise.

Area of Science:

  • Endocrinology
  • Andrology
  • Pharmacology

Background:

  • Nandrolone decanoate (ND) is an anabolic-androgenic steroid with potential to disrupt the hypothalamic-pituitary-gonadal axis and androgen-dependent organs.
  • Indiscriminate use of ND can lead to subclinical alterations, necessitating further investigation into its effects.

Purpose of the Study:

  • To evaluate the impact of ND, alone or combined with resistance exercise (RE), on sex hormones, converting enzymes, and steroid receptors.
  • To assess the morphological changes in the ventral prostate (VP) of adult and aged rats following ND and RE treatments.

Main Methods:

  • Adult and aged Sprague-Dawley rats were divided into four groups: sedentary and trained, with and without ND treatment, over 8 weeks.
  • Hormone levels, enzyme activity (5α-reductase type 2, aromatase), steroid receptor expression (AR, ERs, ERβ), and prostate morphology (epithelial height, PCNA, PAR4) were analyzed.

Main Results:

  • ND treatment decreased testosterone and 17β-estradiol levels in both adult and aged rats.
  • RE increased 5αR2 and aromatase in adult rats' prostates, while aged rats showed decreased aromatase with ND+RE and reduced 5αR2 with RE alone.
  • ND increased ERs in adult rats' prostates, and ERβ levels decreased in aged rats; prostatic epithelial height was reduced in all treated adult animals.

Conclusions:

  • ND, with or without RE, significantly alters sex hormone levels, enzyme activity, and steroid receptor expression in the prostate of adult and aged rats.
  • These findings indicate that ND interferes with the morphophysiology of the prostate, regardless of age or combination with resistance exercise.
Keywords:
apoptosishormonesproliferationresistance exercise trainingsex steroidventral prostate

More Related Videos

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy05:17

Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy

Published on: April 5, 2024

1.3K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.7K

Related Concept Videos

Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
58.8K
Types of Hormones02:13

Types of Hormones

Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.3K
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.8K
Hormonal Regulation01:40

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.0K
Plant Hormones01:56

Plant Hormones

Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.4K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.4K