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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Updated: Jan 26, 2026

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
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In conversation with Sarah Teichmann.

Paraminder Dhillon1, Sarah A Teichmann2,3,4

  • 1The FEBS Journal Editorial Office, Cambridge, UK.

The FEBS Journal
|April 24, 2019
PubMed
Summary
This summary is machine-generated.

Dr. Sarah Teichmann utilizes single-cell genomics to study immune system function and protein interactions. Her work on the Human Cell Atlas initiative maps human cell types, advancing our understanding of cellular genetics.

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Area of Science:

  • Genomics and Bioinformatics
  • Cellular and Molecular Biology
  • Immunology

Background:

  • Dr. Sarah Teichmann leads Cellular Genetics at the Wellcome Sanger Institute and EMBL-EBI.
  • Her research focuses on protein interactions and gene expression, employing advanced single-cell genomics.
  • She co-founded the Human Cell Atlas initiative to comprehensively map human cell types.

Discussion:

  • Explores the power of single-cell transcriptomics and spatial methods in biological research.
  • Highlights breakthroughs in understanding protein complex assembly and gene regulatory networks.
  • Discusses career trajectory and mentorship in scientific research.

Key Insights:

  • Single-cell genomics provides powerful insights into immune system function.
  • The Human Cell Atlas initiative is mapping the cellular landscape of the human body.
  • Understanding gene expression and protein interactions at a single-cell level is crucial.

Outlook:

  • Continued advancement in single-cell technologies will deepen our understanding of cellular diversity.
  • The Human Cell Atlas project promises to revolutionize developmental biology and disease research.
  • Future research will likely focus on integrating multi-omic single-cell data for a holistic view.