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Updated: Jan 26, 2026

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery
Meihui Zhao1, Yu Zhang, Shirui Yuan
1Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China. zhenghongwu66@cpu.edu.cn qixiaole523@cpu.edu.cn.
Abstract:
We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells.
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