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Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes
Georgios Ponirakis1, Ioannis N Petropoulos1, Uazman Alam2,3
1Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
American Journal of Hypertension
|April 24, 2019
Summary
Hypertension worsens diabetic peripheral neuropathy (DPN) in type 1 diabetes mellitus (T1DM) patients, impacting nerve function. This highlights the need for blood pressure management to prevent DPN complications.
Area of Science:
- Neurology
- Endocrinology
- Cardiology
Background:
- Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus.
- DPN can lead to severe outcomes such as foot ulceration and amputation.
- Currently, no disease-modifying therapies exist for DPN.
Purpose of the Study:
- To investigate the association between hypertension and DPN in patients with type 1 diabetes mellitus (T1DM).
Main Methods:
- A comprehensive assessment of DPN was conducted in 70 T1DM subjects and 78 controls.
- Nerve conduction parameters, vibration perception threshold, and corneal nerve fiber density/length were evaluated.
- Statistical analyses were performed to determine associations, adjusting for confounding factors.
Main Results:
- Hypertension was observed in 40 of 70 T1DM subjects and 20 of 78 controls.
- Hypertension correlated with abnormal nerve conduction, increased vibration perception threshold, and reduced corneal nerve fiber density in T1DM patients.
- After adjustments, tibial nerve conduction parameters remained associated with hypertension and systolic blood pressure in T1DM.
Conclusions:
- Hypertension is significantly associated with impaired nerve conduction in T1DM.
- Findings support the potential benefit of blood pressure-lowering agents in managing DPN.
- Larger clinical trials are warranted to confirm the efficacy of antihypertensive therapies for DPN.
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