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An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer

Dinh-Toi Chu1,2,3, Nguyen Duy Bac4, Khanh-Hoang Nguyen5

  • 1Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam. chudinhtoi.hnue@gmail.com.

International Journal of Molecular Sciences
|April 25, 2019
PubMed

Insights

Anti-CD137 antibodies show promise in cancer immunotherapy. These antibodies can be used alone or in combination therapies to enhance anti-cancer immune responses and suppress tumor cells.

Area of Science:

  • Immunology
  • Oncology
  • Pharmacology

Background:

  • CD137 is selectively expressed on immune cells like T cells and dendritic cells, as well as on cancer cells.
  • This selective expression makes CD137 a promising target for developing novel cancer immunotherapies.
  • Antibodies targeting CD137 are being investigated for their potential to modulate anti-cancer immune responses.

Purpose of the Study:

  • To review and synthesize current research on the anti-cancer effects of anti-CD137 antibodies.
  • To discuss the efficacy of anti-CD137 antibodies as monotherapies and in combination with other treatments.
  • To provide an updated perspective on CD137-targeted cancer immunotherapy.

Main Methods:

  • Literature review of preclinical and clinical studies on anti-CD137 antibodies.
  • Analysis of data on the mechanisms of action for anti-CD137 antibodies.
  • Synthesis of evidence regarding the use of anti-CD137 antibodies in various cancer types.

Main Results:

  • Anti-CD137 antibodies can activate immune cells to enhance anti-tumor responses.
  • Some cancers respond to anti-CD137 antibodies as monotherapy.
  • Combination therapies involving anti-CD137 antibodies with other agents show improved efficacy in certain cases.

Conclusions:

  • Anti-CD137 antibodies represent a significant advancement in cancer immunotherapy.
  • The strategic use of anti-CD137 antibodies, both alone and in combination, holds potential for improved cancer treatment outcomes.
  • Further research is warranted to optimize the application of CD137-targeted therapies.
Keywords:
CD137/4-1BBCD137L/4-1BBLanti-CD137 antibodiesanti-CD137 antibody therapycancer immunotherapies

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