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Telomeres and Telomerase02:41

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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In vitro Reconstitution of the Active T. castaneum Telomerase
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Telomerase-Targeted Cancer Immunotherapy.

Eishiro Mizukoshi1, Shuichi Kaneko2

  • 1Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa City, Ishikawa 920-8641, Japan. eishirom@m-kanazawa.jp.

International Journal of Molecular Sciences
|April 25, 2019
PubMed
Summary

Telomerase activation fuels cancer cell proliferation and metastasis. This review explores immunotherapy targeting human telomerase reverse transcriptase (hTERT) as a promising anticancer strategy.

Keywords:
T cellchimeric antigen receptordendritic cellhTERTimmunotherapypeptide vaccine

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Telomerase is crucial for telomere maintenance, enabling uncontrolled cancer cell replication.
  • Activated telomerase supports cancer cell survival, invasion, and metastasis.
  • Targeting telomerase is a key strategy in cancer therapeutics.

Purpose of the Study:

  • To review novel therapeutic strategies targeting telomerase.
  • To focus on immunotherapy targeting human telomerase reverse transcriptase (hTERT).
  • To discuss current evidence and future perspectives for hTERT-targeted immunotherapy.

Main Methods:

  • Review of existing literature on telomerase and cancer therapeutics.
  • Analysis of studies on telomerase inhibitors, telomere DNA targeting drugs, and viral vectors.
  • Focus on research related to immunotherapy targeting hTERT.

Main Results:

  • Telomerase inhibitors and other telomere-targeting agents have been developed.
  • Immunotherapy targeting hTERT represents a novel approach to cancer treatment.
  • Evidence suggests potential efficacy and future development in hTERT-targeted therapies.

Conclusions:

  • Targeting telomerase, particularly hTERT, offers a promising avenue for cancer therapy.
  • hTERT-targeted immunotherapy warrants further investigation and development.
  • Future research should focus on optimizing hTERT-based immunotherapeutic strategies.