Related Experiment Video
Updated: Jan 25, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
Published on: July 14, 2011
Telomerase-Targeted Cancer Immunotherapy
Eishiro Mizukoshi1, Shuichi Kaneko2
1Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa City, Ishikawa 920-8641, Japan. eishirom@m-kanazawa.jp.
Abstract:
Telomerase, an enzyme responsible for the synthesis of telomeres, is activated in many cancer cells and is involved in the maintenance of telomeres. The activity of telomerase allows cancer cells to replicate and proliferate in an uncontrolled manner, to infiltrate tissue, and to metastasize to distant organs. Studies to date have examined the mechanisms involved in the survival of cancer cells as targets for cancer therapeutics. These efforts led to the development of telomerase inhibitors as anticancer drugs, drugs targeting telomere DNA, viral vectors carrying a promoter for human telomerase reverse transcriptase (hTERT) genome, and immunotherapy targeting hTERT. Among these novel therapeutics, this review focuses on immunotherapy targeting hTERT and discusses the current evidence and future perspectives.
More Related Videos
08:34Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
10:14Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol TRAP Assay
Published on: September 2, 2014
Related Concept Videos
Telomeres and Telomerase
Telomeres and Telomerase
Targeted Cancer Therapies
There are several types of targeted therapies against...
Tumor Immunotherapy
Cancer
What is Cancer?
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...