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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
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When CAR Meets Stem Cells.

Jung Min Lee1

  • 1School of Life Science, Handong Global University, Pohang 37554, Korea. jm.lee@handong.edu.

International Journal of Molecular Sciences
|April 25, 2019
PubMed
Summary
This summary is machine-generated.

Human pluripotent stem cells can generate various immune cells for cancer therapy. Combining these cells with chimeric antigen receptor (CAR) technology offers a promising approach for next-generation immunotherapies.

Keywords:
CARCRISPR/Cas9pluripotent stem cell

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Area of Science:

  • Regenerative Medicine
  • Immunology
  • Stem Cell Biology

Background:

  • Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, are a key focus in regenerative medicine.
  • hPSC-derived immune cells like T cells, NK cells, and macrophages show potential for treating cancers.
  • Chimeric antigen receptor (CAR) technology has advanced cancer immunotherapy, particularly with CAR-T cells.

Purpose of the Study:

  • To review the generation of immune cells from hPSCs.
  • To summarize CAR technology and its application in engineering immune cells.
  • To explore the combination of hPSC-derived immune cells and CAR engineering for novel cancer therapies.

Main Methods:

  • Review of existing literature on pluripotent stem cell differentiation into immune lineages.
  • Summary of advancements in CAR technology and engineering strategies.
  • Analysis of the synergistic potential between hPSC-derived immune cells and CAR engineering.

Main Results:

  • Pluripotent stem cells can be differentiated into various functional immune cells.
  • CAR engineering can enhance the anti-cancer efficacy of these immune cells.
  • Combining hPSC-derived immune cells with CAR technology presents a viable strategy for next-generation therapies.

Conclusions:

  • hPSC-derived immune cells offer a renewable source for cell-based therapies.
  • CAR-engineered hPSC-derived immune cells represent a significant advancement in cancer treatment.
  • This approach paves the way for developing innovative and potent immunotherapies.