Related Experiment Video

Updated: Jan 25, 2026

Isolation and Differentiation of Adipose-Derived Stem Cells from Porcine Subcutaneous Adipose Tissues
09:20

Isolation and Differentiation of Adipose-Derived Stem Cells from Porcine Subcutaneous Adipose Tissues

Published on: March 31, 2016

30.0K

The Expression of Adipose Tissue-Derived Cardiotrophin-1 in Humans with Obesity

Jacqueline Stephens1, Eric Ravussin2, Ursula White3

  • 1Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. jsteph1@lsu.edu.

Biology
|April 25, 2019
PubMed

Insights

Cardiotrophin-1 (CT-1) expression in human fat tissue varies by location and is linked to metabolic health. Higher CT-1 in subcutaneous fat may protect against obesity and metabolic syndrome complications.

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Molecular Biology

Background:

  • Cardiotrophin-1 (CT-1) is a cytokine linked to heart failure, obesity, and metabolic syndrome (MetS).
  • Adipose tissue (AT) is an endocrine organ and a source of CT-1, but its human adipose-derived expression is unstudied.
  • Rodent studies suggest CT-1 may be a therapeutic target for obesity and MetS.

Purpose of the Study:

  • To analyze CT-1 mRNA expression in human subcutaneous adipose tissue depots.
  • To investigate the association of adipose-derived CT-1 with clinical variables in obesity and during overfeeding.

Main Methods:

  • Analysis of CT-1 mRNA expression in subcutaneous abdominal (scABD) and femoral (scFEM) adipose tissue depots.
  • Correlation of CT-1 expression with visceral adiposity, intrahepatic lipid, and insulin sensitivity in obese women and men undergoing 8-week overfeeding.

Main Results:

  • CT-1 expression was higher in scABD than scFEM adipose depots.
  • In obese women, scFEM CT-1 expression negatively correlated with visceral adiposity and intrahepatic lipid, and positively with insulin sensitivity.
  • In men, higher baseline CT-1 levels correlated with preserved insulin sensitivity after overfeeding.

Conclusions:

  • Adipose-derived CT-1 expression differs between human subcutaneous fat depots.
  • CT-1 may play a protective role in metabolic health, influencing visceral adiposity and insulin sensitivity in obesity.
  • CT-1 warrants further investigation as a potential therapeutic target for obesity and related metabolic disorders.

Keywords:
abdominaladipose tissuecardiotrophin-1clinical variablesfemoralgp130 cytokinesmetabolic healthobesity

More Related Videos

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy07:24

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Published on: September 29, 2017

7.8K
Isolation and Culture of Human Adipose-Derived Stem Cells With an Innovative Xenogeneic-Free Method for Human Therapy06:00

Isolation and Culture of Human Adipose-Derived Stem Cells With an Innovative Xenogeneic-Free Method for Human Therapy

Published on: February 3, 2023

4.1K

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.2K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
238
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.3K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.3K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
266
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
175