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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression

Xiao-Yan Yang1,2,3, Shigeyuki Ozawa4,5, Yasumasa Kato6

  • 1Oral Health Science Research Center, Graduate School of Kanagawa Dental University, Yokosuka 238-8580, Japan. yang@kdu.ac.jp.

International Journal of Molecular Sciences
|April 25, 2019
PubMed

Insights

Chemokine CXCL14 (BRAK) shows potential for cancer suppression by inhibiting tumor growth. Its context-dependent effects on tumor formation warrant further investigation for novel therapeutic strategies.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Cancer poses a significant global health and economic burden, necessitating innovative tumor suppression strategies.
  • Identifying molecular mechanisms underlying tumor suppression is crucial for developing effective treatments.
  • Chemokines play diverse roles in biological processes, including cancer progression.

Purpose of the Study:

  • To investigate the role of chemokine CXCL14 (BRAK) in cancer progression.
  • To explore the context-dependent effects of CXCL14 on tumor growth and metastasis.
  • To identify potential therapeutic applications of CXCL14 in cancer treatment.

Main Methods:

  • Screening for downregulated molecules in a cancer progression model.
  • Overexpression of CXCL14 in tumor cells and subsequent transplantation in immunodeficient mice.
  • Analysis of tumor growth, metastasis, and chemical carcinogenesis in transgenic mice with altered CXCL14 levels.
  • Review of existing literature on CXCL14 in cancer progression.

Main Results:

  • CXCL14 was significantly downregulated during cancer progression.
  • Increased CXCL14 production suppressed tumor cell growth in vivo.
  • Transgenic mice overexpressing CXCL14 exhibited reduced tumor growth, metastasis, and chemical carcinogenesis.
  • CXCL14 also demonstrated antimicrobial properties.

Conclusions:

  • CXCL14 exhibits context-dependent roles in cancer, acting as a suppressor in some settings and potentially a promoter in others.
  • Further research into the mechanisms underlying CXCL14's dual role is essential for its therapeutic application.
  • CXCL14 represents a promising target for novel cancer therapies, particularly given its potential for tumor suppression and antimicrobial activity.
Keywords:
C-X-C motif chemokine ligand 14antimicrobial functionmolecular preventive medicinemultifunctional tumor suppressor

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