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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Psoriatic arthritis for dermatologists.

Alice Gottlieb1, Joseph F Merola2

  • 1Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY, USA.

The Journal of Dermatological Treatment
|April 25, 2019
PubMed
Summary
This summary is machine-generated.

Dermatologists can detect psoriatic arthritis (PsA) in psoriasis patients early. Prompt treatment prevents joint damage and disability, improving patient quality of life.

Keywords:
Psoriatic arthritisaxial diseasedactylitisdisabilityenthesitisloss of functionperipheral arthritispsoriasispsoriatic nail disease

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Area of Science:

  • Rheumatology and Dermatology
  • Inflammatory Arthritis
  • Comorbidity Management

Background:

  • Psoriatic arthritis (PsA) is a significant comorbidity in up to one-third of psoriasis patients.
  • Delayed treatment initiation for PsA can lead to functional loss and permanent disability.
  • Dermatologists are ideally positioned for early PsA detection in psoriasis patients.

Purpose of the Study:

  • To provide practical guidance for dermatologists in detecting PsA among psoriasis patients.
  • To review treatment options across PsA's six clinical domains.
  • To advise on interpreting PsA clinical trial results.

Main Methods:

  • Review of clinical guidelines and trial data for PsA detection and management.
  • Focus on recognizing PsA across its diverse clinical domains (peripheral arthritis, dactylitis, enthesitis, psoriasis, nail disease, axial disease).
  • Guidance on differential diagnosis considering PsA's heterogeneity and similarity to other arthritic conditions.

Main Results:

  • Early recognition of PsA is crucial for preventing disease progression.
  • PsA can manifest across six distinct clinical domains, with varying patient involvement over time.
  • Effective management requires understanding treatment options tailored to each clinical domain.

Conclusions:

  • Dermatologists play a vital role in the early identification and management of PsA.
  • Timely intervention by dermatologists can mitigate irreversible joint damage and disability.
  • Improved quality of life is achievable through prompt PsA diagnosis and treatment.