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Elevated Triglycerides to High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio Predicts Long-Term Mortality in

Rohullah Sultani1, David C Tong2, Matthew Peverelle1

  • 1Department of Cardiology, St. Vincent's Hospital, Melbourne, Vic, Australia; University of Melbourne, Department of Medicine, St. Vincent's Hospital, Melbourne, Vic, Australia.

Heart, Lung & Circulation
|April 25, 2019
PubMed

Insights

An elevated triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio predicts poor outcomes. This ratio is an independent predictor of long-term mortality and major adverse cardiac events (MACE) in patients with suspected coronary artery disease.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Clinical Biochemistry

Background:

  • The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio is a marker for adverse cardiometabolic risk.
  • Its prognostic value in patients with suspected coronary artery disease (CAD) requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic significance of an elevated TG/HDL-C ratio in an Australian cohort undergoing coronary angiography.
  • To determine if TG/HDL-C ratio predicts mortality and major adverse cardiac events (MACE).

Main Methods:

  • A prospective cohort study of 482 patients undergoing coronary angiography.
  • Patients were stratified based on a TG/HDL-C ratio cut-point of 2.5.
  • Primary endpoint: all-cause mortality; Secondary endpoint: MACE.

Main Results:

  • Higher prevalence of CAD in patients with TG/HDL-C ratio ≥2.5 (83.6% vs. 69.4%, p=0.03).
  • TG/HDL-C ratio ≥2.5 was associated with worse long-term prognosis (p=0.04).
  • Independent predictor of all-cause mortality (HR 2.10, p=0.04) and strongly associated with MACE (OR 2.72, p=0.002) after adjustment.

Conclusions:

  • An elevated TG/HDL-C ratio (≥2.5) is an independent predictor of long-term all-cause mortality.
  • This ratio is strongly associated with an increased risk of major adverse cardiac events (MACE) in patients with suspected CAD.
Abstract

Keywords:
All-cause mortalityAngiographyCoronaryCoronary artery diseaseMajor adverse cardiovascular eventsTriglycerides to high-density lipoprotein cholesterol ratio

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