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Abnormal frontal generator during auditory sensory gating in panic disorder: An MEG study
Chia-Hsiung Cheng1, Pei-Ying S Chan2, Shih-Chieh Hsu3
1Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan.
Psychiatry Research. Neuroimaging
|April 25, 2019
Summary
Patients with panic disorder (PD) have impaired sensory gating (SG), a brain mechanism for filtering information. This study found SG deficits in PD patients
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Panic disorder (PD) is characterized by information processing abnormalities, even with nonthreatening stimuli.
- Previous research suggests a sensory gating (SG) deficit in PD, but neural correlates and clinical associations are unclear.
Purpose of the Study:
- To investigate the neural underpinnings of sensory gating deficits in panic disorder.
- To explore the relationship between sensory gating impairments and clinical symptoms in PD patients.
Main Methods:
- Magnetoencephalography (MEG) recordings were used with an auditory paired-stimulus paradigm.
- 18 patients with PD and 20 healthy controls underwent MEG scans.
Main Results:
- PD patients showed significantly higher M50 SG ratios in the right inferior frontal gyrus (RIFG).
- PD patients exhibited higher M100 SG ratios in both the RIFG and right superior temporal gyrus (RSTG).
- In the RIFG, M50 SG ratios correlated with Body Sensation Questionnaire (BSQ) and Distractibility scores in PD patients.
Conclusions:
- Panic disorder patients demonstrate a deficient ability to filter irrelevant information.
- These sensory gating deficits may contribute to cognitive misinterpretation of somatic sensations and distractibility in PD.
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