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Published on: January 17, 2013
Architectural Principles for Characterizing the Performance of Antithetic Integral Feedback Networks
Noah Olsman1, Fangzhou Xiao2, John C Doyle3
1Department of Control and Dynamical Systems, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215, USA.
Abstract:
As we begin to design increasingly complex synthetic biomolecular systems, it is essential to develop rational design methodologies that yield predictable circuit performance. Here we apply mathematical tools from the theory of control and dynamical systems to yield practical insights into the architecture and function of a particular class of biological feedback circuit. Specifically, we show that it is possible to analytically characterize both the operating regime and performance tradeoffs of an antithetic integral feedback circuit architecture. Furthermore, we demonstrate how these principles can be applied to inform the design process of a particular synthetic feedback circuit.
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