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Related Experiment Videos

Factors affecting proximal tubular reabsorption during development.

F J Kaskel, A M Kumar, E A Lockhart

    The American Journal of Physiology
    |January 1, 1987
    PubMed
    Summary

    Glomerulotubular balance is maintained in guinea pigs by a developing proximal tubule. Initially high permeability compensates for low reabsorption pressure, later decreasing as the tubule matures.

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    Area of Science:

    • Nephrology
    • Developmental Biology
    • Physiology

    Background:

    • Glomerulotubular balance is crucial for kidney function.
    • This balance is maintained during development despite changing regulatory factors.
    • The mechanisms underlying this developmental adaptation are not fully understood.

    Purpose of the Study:

    • To quantify changes in factors controlling glomerulotubular balance in developing guinea pigs.
    • To describe the profile of these adaptations in the proximal tubule epithelium.
    • To elucidate the mechanisms maintaining glomerulotubular balance during postnatal development.

    Main Methods:

    • Measured hydrostatic and oncotic pressures to assess physical forces.
    • Estimated proximal tubule permeability using macromolecule permeance and histologic measurements.

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  • Assessed tubular fluid osmolality (TF/Posm) at the end of the proximal tubule.

    • Main Results:

    • Net reabsorption pressure increased significantly from 15.0 to 30.9 mmHg between 1 and 50 days of age.
    • Proximal tubule permeability to mannitol decreased with age, indicating a reduction in paracellular channel size.
    • Tubular fluid osmolality (TF/Posm) decreased, suggesting increased solute reabsorption and tighter epithelium.

    Conclusions:

    • Early postnatal glomerulotubular balance is facilitated by high proximal tubule permeability compensating for low reabsorption pressure.
    • Maturation involves a tighter epithelium, necessitating increased intercellular channels and active sodium transport for sustained balance.
    • These findings provide insights into kidney development and adaptation.