Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

404
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
404
Multi-Step Reactions02:31

Multi-Step Reactions

8.7K
Chemical reactions often occur in a stepwise fashion involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs. Each of the steps in a reaction mechanism is called an elementary reaction. These...
8.7K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1000
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1000
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.7K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.7K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.0K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

486
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
486

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visual cycle-derived bisretinoids as endogenous natural products: enzyme-free formation, photochemical reactivity, and retinal degeneration.

Natural product reports·2026
Same author

Chromophore-loaded CRALBP restores rod visual cycle in chromophore-deficient mice.

Molecular therapy. Advances·2026
Same author

Disease mechanisms revealed in the P23H opsin knock-in mouse model of retinitis pigmentosa.

PNAS nexus·2026
Same author

More insights from Abca4<sup>-/-</sup> mouse models of recessive Stargardt disease.

The Journal of biological chemistry·2026
Same author

Tracking Systemic and Ocular Vitamin A.

Cells·2026
Same author

Prime editing for the investigation of aberrant splicing defect associated with a pathogenic <i>PRPH2</i> variant.

Molecular therapy. Nucleic acids·2025
Same journal

Application of ephrin-B2 loaded glycol chitosan-silk fibroin hydrogel in the treatment of diabetic refractory wounds.

Scientific reports·2026
Same journal

International expert Delphi consensus on thromboprophylaxis in metabolic and bariatric surgery.

Scientific reports·2026
Same journal

Assessing the cross-region knowledge transfer capability of selected deep learning building vectorization methods in the context of available training datasets.

Scientific reports·2026
Same journal

Feasibility and preliminary effects of outdoor versus indoor cognitive-motor therapy in women with Alzheimer's disease: A randomized single-blind pilot study.

Scientific reports·2026
Same journal

Hallmarks of social action in the vocal turn-taking of wild common marmosets (Callithrix jacchus).

Scientific reports·2026
Same journal

Role and mechanism of AOPPs-induced NOX4-mediated ferroptosis in intervertebral disc degeneration.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

8.0K

Multi-platform imaging in ABCA4-Associated Disease.

Lijuan Chen1,2, Winston Lee1, Jose Ronaldo Lima de Carvalho1,3,4

  • 1Department of Ophthalmology, Columbia University, New York, New York, United States.

Scientific Reports
|April 25, 2019
PubMed
Summary
This summary is machine-generated.

Fundus autofluorescence (FAF) imaging platforms vary in Stargardt disease (STGD1) detection. Ultrawide-field (UWF-AF) and near-infrared (NIR-AF) imaging show foveal sparing better than blue/SW-AF, offering advantages for pediatric patients.

More Related Videos

A Multi-compartment CNS Neuron-glia Co-culture Microfluidic Platform
13:24

A Multi-compartment CNS Neuron-glia Co-culture Microfluidic Platform

Published on: September 10, 2009

12.4K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

20.1K

Related Experiment Videos

Last Updated: Jan 25, 2026

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

8.0K
A Multi-compartment CNS Neuron-glia Co-culture Microfluidic Platform
13:24

A Multi-compartment CNS Neuron-glia Co-culture Microfluidic Platform

Published on: September 10, 2009

12.4K
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

20.1K

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Genetics

Background:

  • Recessive Stargardt disease (STGD1) diagnosis and monitoring rely on fundus autofluorescence (FAF) imaging.
  • FAF imaging platforms differ in field size, excitation wavelength, and image processing, impacting visualization of STGD1 features.

Purpose of the Study:

  • To compare different FAF imaging platforms for their effectiveness in diagnosing and monitoring STGD1.
  • To evaluate how variations in field size and excitation wavelength affect the demonstration of key STGD1 indicators.

Main Methods:

  • Retrospective cohort study of 34 STGD1 patients.
  • Comparison of FAF imaging platforms: 30°/55° (blue/SW-AF, NIR-AF) and 200° ultrawide-field (UWF-AF).
  • Analysis of excitation wavelengths (488nm, 532nm, 787nm) and image processing effects on STGD1 features.

Main Results:

  • Green/UWF-AF and NIR-AF imaging better demonstrated foveal sparing due to reduced macular pigment absorption.
  • A distinct zone of elevated AF and an inferonasal demarcation line were more visible with green/UWF-AF in STGD1 patients.
  • Central atrophic areas appeared larger in NIR-AF images; flecks appeared hypoautofluorescent in NIR-AF but hyperautofluorescent in blue/SW-AF and green/UWF-AF.

Conclusions:

  • Ultrawide-field green/UWF-AF imaging offers advantages for STGD1 assessment, particularly in pediatric patients, as the disease often extends beyond standard imaging fields.
  • Different FAF imaging modalities provide complementary information for comprehensive STGD1 evaluation.
  • FAF imaging variations influence the visibility and characterization of STGD1-related retinal changes.