Related Experiment Video
Updated: Jan 25, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional
Jean Provost1, Anikitos Garofalakis2,3, Joevin Sourdon2,3
1Institut Langevin, Ecole Supérieure de Physique et de Chimie Industrielles, Paris Sciences and Letters Research University CNRS UMR 7587 Inserm U979, Inserm Technology Research Accelerator in Biomedical Ultrasound, Paris, France.
Abstract:
Positron emission tomography-computed tomography (PET-CT) is the most sensitive molecular imaging modality, but it does not easily allow for rapid temporal acquisition. Ultrafast ultrasound imaging (UUI)-a recently introduced technology based on ultrasonic holography-leverages frame rates of up to several thousand images per second to quantitatively map, at high resolution, haemodynamic, biomechanical, electrophysiological and structural parameters. Here, we describe a pre-clinical scanner that registers PET-CT and UUI volumes acquired simultaneously and offers multiple combinations for imaging. We demonstrate that PET-CT-UUI allows for simultaneous images of the vasculature and metabolism during tumour growth in mice and rats, as well as for synchronized multi-modal cardiac cine-loops. Combined anatomical, functional and molecular imaging with PET-CT-UUI represents a high-performance and clinically translatable technology for biomedical research.
More Related Videos
10:21Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
Published on: August 8, 2019
07:03Imaging and Quantification of the Hepatic Vasculature of Mice Using Ultrafast Doppler Ultrasound
Published on: July 19, 2024
Related Concept Videos
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
Molecular Spectroscopy: Absorption and Emission
Emission Spectra
Hybridization of Atomic Orbitals I
Hybridization of Atomic Orbitals II