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Updated: Jun 23, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 27, 2013

Thrombolysis in the treatment of acute transmural myocardial infarction

B Smith, J W Kennedy

    Annals of Internal Medicine
    |March 1, 1987
    PubMed

    Insights

    Thrombolytic therapy, including intravenous and clot-selective agents, offers effective reperfusion for acute myocardial infarction, improving patient outcomes. This review details the evolution of these treatments and outlines a management strategy.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Extensive research since 1980 has focused on acute myocardial infarction (AMI) pathophysiology and mortality.
    • Efforts aim to halt transmural infarction evolution and restore blood flow via infarct-related arteries.

    Purpose of the Study:

    • To review the research progression leading to current thrombolytic agent use in AMI.
    • To propose a patient management program for acute myocardial infarction.

    Main Methods:

    • Review of published data on AMI pathophysiology and thrombolytic therapy.
    • Analysis of intracoronary and intravenous thrombolytic agent efficacy and applicability.
    • Evaluation of clot-selective agents for early intervention.

    Main Results:

    • Intracoronary thrombolysis is effective but logistically challenging.
    • Intravenous thrombolytic therapy expands treatment accessibility without significant efficacy loss.
    • Clot-selective agents show promise for early, safe interruption of infarction.

    Conclusions:

    • Thrombolytic agents have evolved significantly, offering improved reperfusion strategies for AMI.
    • A structured patient management program incorporating these agents is proposed.
    • Continued research supports optimizing AMI treatment through advanced thrombolytic therapies.

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