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Reverse Microemulsion-mediated Synthesis of Monometallic and Bimetallic Early Transition Metal Carbide and Nitride Nanoparticles
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Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen

Jun-Yong Wu1,2,3, Yong-Jiang Li1,2,3, Ting-Ting Liu1,2,3

  • 1Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China, xiangdaxiong@csu.edu.cn.

International Journal of Nanomedicine
|April 25, 2019
PubMed
Abstract

Insights

Microemulsions (MEs) enhance skin delivery of 8-methoxypsoralen (8-MOP) for vitiligo treatment. Chitosan-coated MEs improve retention and reduce systemic exposure, offering a safer alternative for targeted dermal delivery.

Area of Science:

  • Pharmaceutical Sciences
  • Dermatology
  • Nanotechnology

Background:

  • 8-methoxypsoralen (8-MOP) is a key drug in psoralen-ultraviolet A therapy for vitiligo.
  • Poor skin retention and systemic side effects of 8-MOP limit its clinical use.

Purpose of the Study:

  • To develop and evaluate microemulsions (MEs) for enhanced dermal delivery of 8-MOP.
  • To compare the efficacy of chitosan derivative-coated MEs against conventional MEs and tincture for skin retention and permeation.

Main Methods:

  • Formulation of various microemulsions (MEs) with different compositions.
  • Preparation and characterization of chitosan-coated 8-MOP MEs (CC-MEs and HC-MEs).
  • Ex vivo skin retention/permeation studies and in vivo pharmacokinetic analysis.

Main Results:

  • A specific ME formulation showed the highest ex vivo skin retention:permeation ratio.
  • Carboxymethyl chitosan-coated MEs (CC-MEs) and hydroxypropyl chitosan-coated MEs (HC-MEs) demonstrated superior skin retention compared to plain MEs.
  • Plain MEs exhibited higher skin drug concentration (AUCskin) and significantly lower plasma concentration (AUCplasma) than chitosan-coated MEs and tincture.

Conclusions:

  • Microemulsions (MEs) show potential for targeted skin delivery of 8-MOP.
  • Chitosan-coated MEs offer improved skin retention and reduced systemic absorption.
  • Developed MEs represent a promising and safer alternative for vitiligo treatment.
Keywords:
8-methoxypsoralenchitosan-coated microemulsionex vivo permeationmicrodialysismicroemulsionpharmacokinetics

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