Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria
Ross D Ballantine1, Conor E McCallion1, Elie Nassour2
1School of Chemistry and Chemical Engineering , David Keir Building , Queen's University Belfast , Stranmillis Road , Belfast , BT9 5AG , UK .
Abstract:
Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-allo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.
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