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Related Experiment Videos

Hypothyroxinemia in cardiac arrest.

J Wortsman, B N Premachandra, I J Chopra

    Archives of Internal Medicine
    |February 1, 1987
    PubMed
    Summary

    Thyroid function tests show significant abnormalities in cardiac arrest (CA) patients, with most experiencing low triiodothyronine and high reverse triiodothyronine. These thyroid function alterations worsen shortly after cardiac arrest.

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    Area of Science:

    • Endocrinology
    • Cardiovascular Medicine
    • Critical Care

    Background:

    • Cardiac arrest (CA) is associated with significant physiological stress, including activation of the pituitary-adrenal axis.
    • Thyroid hormone levels can be affected by critical illness, but data specific to CA is limited.

    Purpose of the Study:

    • To evaluate thyroid function in patients experiencing cardiac arrest (CA).
    • To compare thyroid function abnormalities in CA patients versus intensive care unit (ICU) controls.

    Main Methods:

    • Blood samples were collected from 24 CA patients immediately after diagnosis and 10 minutes later.
    • Thyroid function indexes (T3, T4, free T4, reverse T3), thyroxine-binding globulin, prealbumin, and a thyroid hormone-binding inhibitor were measured.
    • 22 ICU patients without CA served as controls.

    Main Results:

    • CA patients exhibited significantly higher rates of abnormal thyroid function compared to ICU controls.
    • Abnormalities included low triiodothyronine (T3) in 84%, low thyroxine (T4) in 65%, low free T4 in 65%, and high reverse T3 in 80% of CA patients.
    • Thyroid function abnormalities worsened between 0 and 10 minutes post-CA.

    Conclusions:

    • Thyroid function test abnormalities are extremely common in patients with cardiac arrest.
    • These findings highlight the profound impact of CA on the thyroid axis.

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