Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Principles of Disease Surveillance01:26

Principles of Disease Surveillance

486
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
486
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

7.9K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
7.9K
Cancer02:18

Cancer

53.9K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.9K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.4K
What is Cancer?02:12

What is Cancer?

14.1K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.1K
tRNA Activation02:26

tRNA Activation

22.7K
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
22.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Signatures of Dark Matter Annihilation in the Galactic Center with HAWC.

Physical review letters·2026
Same author

Nivolumab plus gemcitabine-cisplatin for unresectable or metastatic urothelial carcinoma: health-related quality-of-life analyses from the phase III CheckMate 901 trial.

ESMO open·2026
Same author

Charge Radii Measurements of Exotic Tin Isotopes in the Proximity of N=50 and N=82.

Physical review letters·2025
Same author

Larcher et al. The OpeRa trial: the active role of the patient in the clinical decision-making process and surgical planning.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Final analysis of nivolumab plus cabozantinib for advanced renal cell carcinoma from the randomized phase III CheckMate 9ER trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Impact of sociodemographic and socioeconomic factors on functional and health-related quality of life outcomes 24 months after radical prostatectomy.

Journal of cancer research and clinical oncology·2025

Related Experiment Video

Updated: Jan 25, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

711

[Active surveillance in prostate cancer].

E Erne1, S Kaufmann2, K Nikolaou2

  • 1Klinik für Urologie, Eberhard Karls Universität Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Deutschland.

Der Urologe. Ausg. A
|April 25, 2019
PubMed
Summary

Active surveillance for low-risk prostate cancer defers curative treatment, minimizing toxicity while maintaining survival. This strategy involves regular monitoring through PSA tests, biopsies, and exams for eligible patients.

Keywords:
BiomarkersGleason scoreMetastasisProstate-specific antigenRadical prostatectomy

More Related Videos

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.8K

Related Experiment Videos

Last Updated: Jan 25, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

711
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.8K

Area of Science:

  • Oncology
  • Urology

Background:

  • Prostate cancer is a leading malignancy in men globally.
  • Low-risk prostate cancer has minimal metastasis and mortality risk, making surveillance a viable option.
  • Active surveillance postpones definitive treatment to reduce toxicity without compromising cure.

Purpose of the Study:

  • To outline the principles and criteria for active surveillance in prostate cancer management.
  • To emphasize minimizing treatment-related toxicity while preserving patient survival.

Main Methods:

  • Defining eligibility criteria for active surveillance: prostate-specific antigen (PSA) ≤10 ng/ml, Gleason score ≤6, clinical stage T1 or T2a, and limited cancer involvement in biopsy cores.
  • Implementing a follow-up protocol including serial PSA measurements, digital rectal examinations, and repeat biopsies.

Main Results:

  • Active surveillance is a safe and effective strategy for select low-risk prostate cancer patients.
  • The defined criteria and follow-up methods enable effective tumor monitoring.

Conclusions:

  • Active surveillance is a recommended approach for men with low-risk prostate cancer.
  • This strategy effectively balances cancer management with the reduction of treatment side effects.