Related Experiment Video
Updated: Jan 25, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Novel Non-biologic Targets for Inflammatory Bowel Disease
Tushar Shukla1, Bruce E Sands2
1Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1069, New York, NY, 10029, USA.
Novel non-biologic therapies are emerging for inflammatory bowel disease (IBD) treatment. Agents like tofacitinib, ozanimod, and apremilast show promise for inducing remission and healing in IBD patients.
Area of Science:
- Gastroenterology
- Pharmacology
- Immunology
Background:
- Biologic therapies transformed inflammatory bowel disease (IBD) management, moving beyond corticosteroids and immunomodulators.
- Current IBD treatment strategies are evolving to include innovative non-biologic agents.
Purpose of the Study:
- To review the latest advancements in non-biologic therapies for inflammatory bowel disease (IBD).
- To highlight novel agents and their efficacy in inducing and maintaining remission and mucosal healing.
Main Methods:
- Comprehensive electronic database search (PubMed, Web of Science, Google Scholar, Scopus) up to September 2018.
- Inclusion of abstracts from major gastroenterology congresses (DDW, ECCO, CDDW, UEG Week).
Main Results:
- Tofacitinib (JAK1/3 inhibitor) demonstrated efficacy in inducing and maintaining remission and mucosal healing in ulcerative colitis (UC).
- Ozanimod (S1P receptor agonist) showed benefits in clinical remission and mucosal healing for UC patients.
- Other non-biologics, including AJM300 and apremilast (PDE4 inhibitor), exhibited positive outcomes in UC.
- Upadacitinib and filgotinib show early promise in Crohn's disease (CD) patients, with ongoing trials.
Conclusions:
- Non-biologic agents represent a diverse and growing class of therapies for IBD.
- These novel agents offer potential for safe and effective oral treatment options for IBD patients.
- The development of non-biologics signifies a significant advancement in IBD therapeutic strategies.
More Related Videos
09:04DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
07:45Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
Published on: September 1, 2017
Related Concept Videos
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...